The Science and History of Ebola
What is Ebola?
Ebola is a rare and deadly disease caused by infection with one of the Ebola virus species. Ebola can cause disease in humans and nonhuman primates (monkeys, gorillas, and chimpanzees).
Ebola is caused by infection with a virus of the family Filoviridae, genus Ebolavirus. There are five identified Ebola virus species, four of which are known to cause disease in humans: Ebola virus (Zaire ebolavirus); Sudan virus (Sudan ebolavirus); Taï Forest virus (Taï Forest ebolavirus, formerly Côte d’Ivoire ebolavirus); and Bundibugyo virus (Bundibugyo ebolavirus). The fifth, Reston virus (Reston ebolavirus), has caused disease in nonhuman primates, but not in humans.
Ebola viruses are found in several African countries. Ebola was first discovered in 1976 near the Ebola River in what is now the Democratic Republic of the Congo. Since then, outbreaks have appeared sporadically in Africa.
The natural reservoir host of Ebola virus remains unknown. However, on the basis of evidence and the nature of similar viruses, researchers believe that the virus is animal-borne and that bats are the most likely reservoir. Four of the five virus strains occur in an animal host native to Africa. Humans can become infected when they come into contact with either the reservoir host or other infected animals. Often this is through bushmeat hunting and butchering.
Dr. Pierre Rollin, head of CDC’s Viral Special Pathogens Branch in the National Center for Emerging Zoonotic Infectious Diseases during the epidemic and a world expert on Ebola, discusses a 1996 outbreak of Ebola in Gabon that was contained to one village. (Transcript)
Once a human is infected with Ebola virus, person-to-person transmission is how the virus spreads and the epidemic grows. People who have Ebola can have virus present in their blood, organs (including skin), and bodily fluids (sweat, saliva, urine, stool). People who come into direct contact with a person sick with Ebola or their bodily fluids can become infected themselves. The levels of virus in a person sick with Ebola increase as a person becomes more ill, and patients who die from the disease have very high quantities of virus present. As a result, contact with a corpse of a patient who has died can also transmit infection.